Europe’s transformations is the unifying theme for this collective work that brings together leading academics and policy makers from across Europe and beyond. When the geopolitical tectonic plates are shifting, the sustainability of the Western economic model is under serious challenge, and internal divisions in Europe are deep, we aim to look at the major issues in a ‘big picture’ perspective. We draw lessons from the way Europe has responded or not to changes both within and without in multiple crises in recent years, try to understand what is at stake, and consider alternative policy proposals. All our authors have long experience and widely recognized knowledge of a wide range of issues concerning European integration and Europe’s role in the world. They cross academic and professional boundaries and bring different perspectives as top analysts and policy makers, including two former prime ministers and a former US ambassador to the EU. They come together as friends, colleagues, and former students of Loukas Tsoukalis, celebrating his scholarship and overall contribution to the European public sphere. The volume is divided into three main parts. The first deals with issues of democracy and welfare. The second part deals with major changes in the European balance of power and the balance between institutions. The third part examines changes in the global system and Europe’s present and potential role within it.